Design and Synthesis of Novel Hybrid Molecules against Malaria

Scheme 5

Synthesis of the hybrid compound 15 (ratio 1 : 1) and of substance 17 (ratio 1 : 2) by the divergent synthetic route using a C3-piperazine-C3 linkage. Reagents and conditions: (a) 3-bromopropionyl chloride (19), NaOAc, DCM (dry), −20°C; (b) NaN₃, DMF (dry), 25°C; (c) PPh₃, MeOH (dry), 25°C; (d) 4,7-dichloroquinoline (0.75 equivalents), neat, 120°C; (e) 4,7-dichloroquinoline (3 equivalents), neat, 120°C.