Research Article
Design and Synthesis of Novel Hybrid Molecules against Malaria
Scheme 6
Synthetic route of the hybrid molecules 16 and 18 with higher basic molecule properties. Reagents and conditions: (a) LiAlH4, THF (dry), 80°C; (b) 4,7-dichloroquinoline (0.8 equivalents), neat, 120°C; (c) 4,7-dichloroquinoline (five equivalents), neat, 120°C.