Research Article
Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents
Table 4
Results of docking studies for reported pyrazole-3-one molecules and their binding interactions with residues within 3 Å radius.
| Reference compound | Number of hydrogen bonds | Hydrogen bond distance | Group of compounds | Group of amino acids | Residue number |
| R1 |
2 | 2.022 | –C=O | –NH | Ser342 | 2.094 | –C=O | –NH | Glu343 | R2 | 1 | 2.470 | –C=O | –NH | Ser342 | R3 |
2 | 1.982 | –C=O | –NH | Ser342 | 2.066 | –C=O | –NH | Glu343 |
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