Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents

Table 6

Amino acid interactions within 3 Å distance from the compound.

Compound	Amino acid interaction
1	Ser 342	Glu 343	Gly 344	Arg 288	Cys 285	Met 348	Ile 341
	*	*	—	—	—	—	—
3	His 449	Tyr 327	Cys 285	Ile 281	Val 339	Met 348	His 323
	*	—	—	—	—	—	—
4	Pro 269	Ser 342	Thr 268	Gly 264	Cys 285	Phe 287	Leu 270
	—	*	—	—	—	—	—
5	Met 288	Ile 281	Cys 285	Gly 284	Arg 288	Val 339	Leu 340
	*	—	—	—	—	—	—
6	Ser 342	Glu 343	Gly 344	Leu 340	Cys 285	Gly 284	Met 348
	*	*	—	—	—	—	—
Rosiglitazone	Glu 343	Ser 342	Cys 285	Gly 284	Ser 289	Gly 344	Ala 292
	—	*	—	—	*	—	—

— means absence of interaction; * means interaction.