Research Article

Benzyl-1,2,4-triazoles as CB1 Cannabinoid Receptor Ligands: Preparation and In Vitro Pharmacological Evaluation

Table 1

Affinity of compounds 7a-8a and 10a–12a and the reference cannabinoids SR141716 and LH21 for CB1R determined using rat cerebellar membranes and [3H]-SR141716 or [3H]-WIN552122 as radioligand. values were obtained from three independent experiments carried out in triplicate and are expressed as mean standard error.

Compound (nM) CB1R versus [3H]-SR141617 (nM) CB1R versus [3H]-WIN552122

SR1417164
LH21
7a
8a
10a
11a
12a