Syntheses and Antibiotic Evaluation of 2-[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonylbenzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues

Table 4

Minimum bactericidal/fungicidal concentration (MBC/MFC) (μg/mL).

Test organism	Z1	Z2	Z3	Z5	Z7	Z8	Z9	Z10	Z11	Z12
MRS	25	12.5	—	—	50	12.5	—	12.5	12.5	—
VRE	—	50	—	12.5	—	50	50	25	—	50
S. aureus	25	12.5	50	—	50	25	—	12.5	12.5	25
S. pyogenes	25	—	25	25	—	—	25	—	—	25
C. ulcerans	—	25	50	—	25	—	25	—	—	—
E. coli	12.5	25	25	12.5	25	50	12.5	12.5	25	25
P. vulgaris	—	—	25	12.5	25	—	—	—	25	25
P. aeruginosa	—	25	—	50	—	—	25	—	—	25
K. pneumonia	25	12.5	12.5	—	12.5	12.5	12.5	12.5	12.5	25
S. typhi	—	—	25	—	—	—	25	12.5	—	50
S. dysenteriae	12.5	25	—	12.5	12.5	25	25	12.5	25	—
C. albicans	50	—	25	25	—	12.5	50	12.5	12.5	25
C. krusei	25	12.5	—	25	25	25	50	12.5	50	25
C. tropicalis	—	25	—	50	—	25	25	12.5	50	50
C. stellatoidea	25	25	12.5	12.5	25	12.5	50	25	25	50

—: no MBC/MFC.