Sl. number Analogues name Analogues structure Antimicrobial activity Reference 1 (−)-Platencin Inhibits both FabF and FabH with similar potency [12 ] 2 7-Phenylplatensimycin MIC against S. aureus (MSSA), 0.25 μ g/mL [15 ] 3 11-Methyl-7-phenylplatensimycin MIC against S. aureus (MSSA), <0.25 μ g/mL [15 ] 4 Sulfonamide analogues of platensimycin Not tested [16 ] 5 Oxazinidinyl platensimycin MIC of 90 μ g/mL against S. aureus , S. agalactiae , and B. subtilis [17 ] 6 Isoplatencin MIC against S. aureus (MSSA), 0.4 μ g/mL [18 ] 7
Cl-iso -platencin MIC against S. aureus (MSSA), >25.6 μ g/mL [18 ] 8 Cl-platencin MIC against S. aureus (MSSA), >25.6 μ g/mL [18 ] 9 Dehydrohomoplatencin MIC against S. aureus (MSSA), 0.4 μ g/mL [19 ] 10 Isoplatensimycin MIC against S. aureus (MSSA), 128 μ g/mL [20 ] 11 Carbaplatensimycin MIC against S. aureus , 0.4–1.1 μ g/mL [21 ] 12 Platensimycin B1 and B3 Not tested [22 ] 13 Platensimide A Not tested [22 ] 14 Homoplatensimide A and homoplatensimide A methyl ester Not tested [22 ] 15 Dialkylamino-2,4-dihydroxybenzoic acids analogues of Platensimycin Out of 18 Synthesized derivatives, four derivatives which have the substitution 1, 2, 3, and 4, respectively, have shown potential activity against B . subtilis (MIC 2–8 μ g/mL) [23 ] 16 (−)-nor-platencin MIC against S. aureus (MSSA), 5 μ g/mL [24 ] 17 Adamantaplatensimycin MIC of (−)-adamantaplatensimycin against S. aureus (MSSA), 1.3–1.8 μ g/mL; MIC of (+)-adamantaplatensimycin against S. aureus (MSSA), >88 μ g/mL [25 ]