Figure 6: Simplified topology of a typical synthetic thiazolidinedione PPARγ agonist. Geometry optimization results in a “U” shaped molecule. Head is thiazolidinedione which is acidic, polar. L1 is Linker, with not more than three carbon atoms. Ar is central aromatic/heteroaromatic ring. L2 is Linker, up to four atoms of carbon, heteroatoms. Tail is large, lipophilic groups like aromatic/heteroaromatic rings.