Table 1: Pharmacological and chemical classification of PPARγ agonists.

(I) Strong/full PPARγ agonists

(1) Endogenous ligands:9-HODE, 13-HODE, 15-deoxy-12,14-prostaglandin J2,
Prostaglandin PGJ2
(2) Natural ligands of plant origin:
 (a) Unsaturated fatty acids and hydroxy unsaturated fatty acids
 (b) Flavonoids:Luteolin, Quercetin, Kaempferol, (-) Catechin
2-hydroxychalcone, Biochanin A, Genistein,
6-hydroxydaidzein
 (c) Stilbenes:Resveratrol, Amorphastilbol
 (d) Amorfrutins:Amorfrutin 1, Amorfrutin 2, Amorfrutin 3
 (e) Polyacetylenes:Falcarindiol
 (f) Sesquiterpene lactones:Deoxyelephantopin
 (g) Diterpene quinone derivatives:Sargaquinoic acid, Sargahydroquinoic acid
(3) Synthetic strong PPARγ agonists:
 (a) Thiazolidinediones or Glitazones:Rosiglitazone, Pioglitazone, Troglitazone, Ciglitazone Rivoglitazone, Englitazone
 (b) Non-thiazolidinediones:
 (i) L-tyrosine analogue:Farglitazar
 (ii) Sulfonamide derivative:INT 131

(II) Selective/partial PPARγ agonists

(1) Thiazolidinediones:Balaglitazone
(2) Benzodiazole derivative:Telmisartan

(III) DUAL PPARα/γ AGONISTS

(1) Thiazolidinediones:Netoglitazone, experimental compounds KRP 297,
MK 767, DRF 2189
(2) Glitazars or non-thiazolidinedionesMuraglitazar, Tesaglitazar, Navaglitazar, Ragaglitazar Aleglitazar

(IV) PPAR panagonists (agonists of PPARα/β/γ subtypes)

(1) Fibrate drugBenzafibrate
(2) Miscellaneous, non-thiazolidinedione derivativeChiglitazar
(3) Fibric acid derivativeExperimental compound ZBH201102
(4) Thiazole derivativeGW-677954
(5) Oxazole derivativeLY-465608

(V) SPPARγM (selective PPARγ modulator)
(Phenylacetic acid derivative)
Metaglidasen

(VI) NOVEL PPARγ/FFAR1 DUAL AGONISTS

(1) ThiazolidinedionesExperimental compounds KM-1, KM-2, KM-5

Compounds have been withdrawn from market or discontinued from clinical trials.