International Journal of Medicinal Chemistry / 2017 / Article / Fig 4

Research Article

Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics

Figure 4

Intracellular cAMP levels in lymphocytes after incubation with vehicle, 1 µM CGS, and 1 µM CGS plus 1 μM of compounds 4 (preladenant), 2731, 5a (tozadenant), 40, 2 (KW-6002), and 3 (KW-PEG) are shown. The intracellular cAMP levels were determined 15 min following stimulation using quantitative cAMP ELISA and are expressed as fmol/106 cells. Data shown represent mean ± SEM of triplicate samples.

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