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International Journal of Medicinal Chemistry
Volume 2017, Article ID 4852537, 8 pages
Research Article

Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics

1Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
2New England Tissue Protection Institute, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
3Gordon Center for Medical Imaging and Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA
4Clinical and Translational Science Institute, Tufts University, 800 Washington Street, Boston, MA 02111, USA

Correspondence should be addressed to Graham B. Jones; ude.stfut@senoj.maharg

Received 15 May 2017; Revised 31 August 2017; Accepted 13 September 2017; Published 19 October 2017

Academic Editor: Rosaria Volpini

Copyright © 2017 Gengyang Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Experimental procedures for chemical synthesis and evaluation of compounds.

  1. Supplementary Material