Synthesis, Antimicrobial, and Computational Evaluation of Novel Isobutylchalcones as Antimicrobial Agents

Table 1

Antibacterial and antifungal activities of chalcones (MIC in µg/mL).

Compound	R	Bs	Sa	Ec	Pv	An	Ct
A1	4′′-Chlorophenyl	32	32	64	64	32	64
A2	4′′-Methylphenyl	256	128	128	128	256	256
A3	2′′,4′′-Dichlorophenyl	16	16	16	16	16	16
A4	2′′-Chlorophenyl	64	64	128	128	64	64
A5	4′′-Fluorophenyl	32	32	64	64	16	32
A6	2′′,4′′-Difluorophenyl	16	16	16	16	16	16
A7	4′′-Dimethylaminophenyl	256	128	256	256	128	64
A8	3′′-Bromophenyl	128	128	128	128	64	128
A9	4′′-Hydroxyphenyl	64	64	64	64	128	128
A10	3′′-Hydroxyphenyl	256	256	128	256	128	64
A11	4′′-Nitrophenyl	128	64	64	128	64	64
A12	4′′-Methoxyphenyl	128	128	256	128	32	16
A13	3′′,4′′-Dimethoxyphenyl	256	128	256	128	64	128
A14	3′′,4′′,5′′-Trimethoxyphenyl	128	128	128	256	32	32
A15	2′′-Pyridinyl	64	128	64	128	32	64
A16	3′′-Pyridinyl	64	128	128	64	64	128
A17	4′′-Pyridinyl	64	128	128	64	32	16
A18	2′′-Pyrrolyl	128	256	128	256	64	32
A19	2′′-Thienyl	128	256	256	256	32	64
A20	5′′-Bromofuran-2′′-yl	64	128	64	128	64	32
A21	3′′,4′′-Methylenedioxyphenyl	256	256	64	64	64	128
A22	9′′-Anthracenyl	128	256	128	128	32	32
A23	1′′-Phenyl-3′′-methylpyrazole-4′′-yl	256	128	128	256	128	64
A24	3′′-Methoxy-4′′-hydroxyphenyl	264	128	64	64	64	32
A25	2′′-Chloro-5-nitrophenyl	64	64	32	32	64	32
Ampicillin		<1	<1	<1	<1	--	--
Fluconazole		--	--	--	--	<2	<2

Bs = Bacillus subtilis; Sa = Staphylococcus aureus; Ec = Escherichia coli; Pv = Proteus vulgaris; An = Aspergillus niger; Ct = Candida tropicalis.