Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility

Figure 4

((a) and (b)) 2D and 3D representation of the binding mode of compound 9 in the tubulin binding site. ((c) and (d)) 2D and 3D representation of the binding mode of compound 10 in the tubulin binding site. ((e) and (f)) 2D and 3D representation of the binding mode of griseofulvin (1) in the tubulin binding site. ((g) and (h)) 2D and 3D representation of the binding mode of taxol in the tubulin binding site.

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