International Journal of Medicinal Chemistry / 2017 / Article / Tab 1

Research Article

Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility

Table 1

Interaction energies and in vitro cytotoxic activities of taxol, 5-fluorouracil, tamoxifen, griseofulvin 1, compound 3, and target compounds 510.

Compound name/numberIsomer (Kcal/mole)IC50 (μM) against HCT116IC50 (μM) against MCF-7

5-Fluorouraciln.t.19.50n.t.
Tamoxifenn.t.n.t.10.00
Taxol−7.9426n.t.n.t.
Griseofulvin−6.139935.5069.00
3−6.943435.8032.80
5−7.0208>10020.70
−7.1249
6−6.671487.84 55.87
−6.6542
7−6.742185.6054.54
−6.7534
8−7.251639.8025.30
−7.2894
9−7.376510.5021.50
−7.3482
10−7.48108.3914.50
−7.5143

n.t.: not tested.

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