International Journal of Medicinal Chemistry / 2017 / Article / Tab 3

Research Article

Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility

Table 3

(nm) and equilibrium solubility of tested compounds 510 at pH 1.2 and 6.8 buffer solutions.

Compound (nm)Mean solubility (μg/ml) ± SD
pH 1.2pH 6.8pH 1.2pH 6.8

129229212.32 ± 0.2912.37 ± 0.26
3294.5295.611.13 ± 0.3711.09 ± 0.82
529429414.26 ± 0.4227.94 ± 0.27
6294.5291.514.86 ± 0.1214.51 ± 0.39
729329431.49 ± 0.7218.32 ± 0.46
8294.5295.829.13 ± 0.7212.53 ± 0.54
9292.5293.513.97 ± 0.3113.78 ± 0.07
10290.5294.626.67 ± 0.5716.58 ± 0.58

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