Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates

Table 1

Anti-inflammatory activity of tested compounds at a dose molecularly equivalent to 20mg/Kg Diclofenac.

Compound	Percentage inhibition at different time intervals (inhibition ± SEM)
	1 hour	2 hours	3 hours	4 hours
Diclofenac	20.71 ± 8.0	20.34 ± 1.5	51.36 ± 9.7	47.99 ± 6.4
M1	18.05 ± 2.1	55.90 ± 9.1	37.12 ± 6.4	41.61 ± 9.0
M2	52.75 ± 1.7	61.32 ± 1.7	34.23 ± 5.0	29.47 ± 4.1
M4	19.35 ± 1.8	43.13 ± 11.3	29.63 ± 5.3	50.39 ± 6.6
M7	42.40 ± 8.4	46.76 ± 3.3	30.23 ± 2.4	54.52 ± 2.8
M8	41.03 ± 8.9	24.91 ± 9.4	47.83 ± 2.1	60.48 ± 6.5

Data analyzed by one way ANOVA followed by Dunnett’s test (n=5). P<0.05 and P<0.01.