Table 2: Minimum inhibitory concentrations (MICs) and minimum microbicidal concentrations (MMCs) (µg/ml) of compound 7 and its entire precursors against fungal and bacterial strains.

MicroorganismsInhibition parameters3467Reference

Gram-positive bacteria
Bacillus subtilis MIC64166482
MBC25632>256322
S. aureusMIC64163220.5
MBC>256326480.5
Gram-negative bacteria
E. coli S2(1)MIC64323282
MBC25664>256322
S. flexneri MIC12832128168
MBC256>256>256328
P. aeruginosa MIC1281612884
MBC>25632>256324
V. cholerae NB2MIC>2562562566432
MBCnd>256>25612832
V. cholerae SG24MIC>256>256>25612864
MBCndndnd25664
V. cholerae CO6MIC25664>256328
MBC>256128nd648

Yeasts
C. parapsilosis ATCC22019MIC6443242
MFC25686442
C. albicans ATCC9002MIC6486444
MFC>2561612884
C. neoformans IP95026MIC324842
MFC12881642

for bacteria and nystatin for yeasts; nd: not determined; compounds 1, 2, and 5 were not tested.