Genetic Variants in the SORL1 Gene Are Associated with Age at Onset of Alzheimer Disease: A Survival Analysis

Table 3

Top 6 SNPs associated with the age at onset of Alzheimer’s disease using the Cox proportional hazards model.

SNP	Male	Mean	HR^a	95% CI^b		Female	Mean	HR	95% CI
rs1784934
AA	42	70.6	1.39	1.00–1.93	0.049	59	72.9	1.01	0.76–1.32	0.962
AG + GG	292	72.0	1.00			398	73.5	1.00
rs676759
GG	53	69.8	1.46	1.09–1.97	0.0121	65	73.4	0.99	0.76–1.29	0.937
AA + AG	281	72.2				392	72.5	1.00
rs560573
TT	53	69.7	1.47	1.09–1.97	0.0117	63	73.5	0.97	0.74–1.27	0.845
AA + AT	281	72.2	1.00			394	72.4	1.00
rs593769
CC	53	69.7	1.47	1.09–1.97	0.0117	65	73.4	0.99	0.76–1.29	0.937
CT + TT	281	72.2	1.00			392	72.5	1.00
rs11218313
AG + GG	45	74.2	0.72	0.53–0.99	0.0459	80	72.6	0.98	0.77–1.26	0.897
AA	289	71.4	1.00			377	72.6	1.00
rs17125558
CT + TT	14	71.4	1.08	0.63–1.85	0.772	25	70.1	1.50	1.00–2.25	0.0494
CC	320	71.8	1.00			432	72.7	1.00

^aHR refers to hazard ratio; ^bCI refers to confidence interval.