Genetic Variants in the SORL1 Gene Are Associated with Age at Onset of Alzheimer Disease: A Survival Analysis

Table 4

Association results for 8 SNPs and the age at onset of Alzheimer’s disease using the linear regression model.

SNP	Position	A1^a	-all^b	-all^c	EMP1^d	-male^e	-male^f	EMP-male^g	-female^h	-female^i	EMP-female^j
rs1784934	121467284	C	0.08	0.865	0.865	−0.71	0.296	0.295	0.65	0.261	0.258
rs676759	121488556	G	0.14	0.749	0.752	−0.78	0.240	0.242	0.85	0.144	0.147
rs560573	121490175	T	0.13	0.764	0.767	−0.77	0.238	0.24	0.85	0.148	0.15
rs593769	121493294	C	0.12	0.784	0.788	−0.79	0.223	0.225	0.83	0.152	0.157
rs11218313	121512162	G	0.96	0.225	0.225	2.82	0.0326	0.0318	−0.09	0.93	0.935
rs2282649	121608249	T	0.97	0.0394	0.0374	0.67	0.359	0.365	1.15	0.0636	0.0637
rs726601	121610698	T	0.96	0.0382	0.0367	0.77	0.287	0.296	1.06	0.083	0.0844
rs17125558	121003094	T	−1.78	0.648	0.653	−0.46	0.881	0.883	−2.61	0.67	0.657

^aMinor allele; ^b refers to the regression coefficient of the linear regression for all patients; ^c value refers to the Wald test asymptotic value for all patients; ^dempirical value for all patients generated by 100,000 permutation tests using Max (T) permutation procedure; ^e refers to the regression coefficient of the linear regression for male patients; ^f value refers to the Wald test asymptotic value for male patients; ^gempirical value for male patients generated by 100,000 permutation tests using Max (T) permutation procedure; ^h refers to the regression coefficient of the linear regression for female patients; ⁱ value refers to the Wald test asymptotic value for female patients; ^jempirical value for female patients generated by 100,000 permutation tests using Max (T) permutation procedure.