The Association of 5-HTTLPR XLL Genotype with Higher Cortisol Levels in African Americans
Table 2
Mean salivary cortisol concentrations by 5-HTTLPR genotypes.
Genotype ()
AM cortisol (nmol/L)
PM cortisol (nmol/L)
Mean cortisol (nmol/L)
Diurnal cortisol (nmol/L)
VNTR
LL (117)
11.1 ± 0.96
5.9 ± 0.67
8.5 ± 0.70
5.1 ± 0.88
LS (84)
10.6 ± 1.49
8.0 ± 1.57
9.3 ± 1.44
*2.6 ± 1.04
SS (22)
14.3 ± 3.13
6.4 ± 1.60
10.4 ± 2.26
8.0 ± 2.07
XLL (5)
*33.8 ± 16.75
*22.8 ± 17.26
*28.3 ± 14.77
†11.0 ± 16.86
SNP
AA (157)
11.1 ± 1.12
7.3 ± 1.07
9.5 ± 1.04
4.6 ± 0.89
AG (64)
11.8 ± 1.30
7.2 ± 0.94
9.5 ± 0.92
4.5 ± 1.33
GG (7)
9.4 ± 1.36
3.3 ± 1.04
6.3 ± 0.96
6.1 ± 1.47
FN
(67)
10.2 ± 1.33
4.9 ± 0.88
7.5 ± 1.00
5.4 ± 1.01
(126)
11.6 ± 1.21
8.1 ± 1.18
9.9 ± 1.09
†3.5 ± 1.00
S+S+ (47)
11.7 ± 1.78
5.8 ± 1.02
8.7 ± 1.32
5.9 ± 1.21
(5)
*33.8 ± 16.75
*22.8 ± 17.26
*28.3 ± 14.77
11.0 ± 16.86
Study concentration average of cortisol ± SE by genotype for morning and evening. Mean cortisol is the calculated average between morning and evening cortisol for the study while diurnal cortisol is the difference between morning and evening levels. *indicates significance at < 0.05; †indicates trend < 0.10 and >0.05.
