Table of Contents
International Journal of Molecular Imaging
Volume 2011 (2011), Article ID 141593, 7 pages
http://dx.doi.org/10.1155/2011/141593
Review Article

Role of SPECT and SPECT/CT in the Surgical Treatment of Primary Hyperparathyroidism

Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA

Received 11 August 2010; Revised 26 March 2011; Accepted 8 April 2011

Academic Editor: J. M. Mountz

Copyright © 2011 Michele L. Taubman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Bilezikian, A. A. Khan, and J. T. Potts Jr., “Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 2, pp. 335–339, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. F. Mandl, “Therapeutischer versuch bein einem falls von otitis fibrosa generalisata mittles. Exstirpation eines epithelkorperchentumors,” Wien Klin Wochenschr Zentral, vol. 53, pp. 260–264, 1926 (German). View at Google Scholar
  3. W. R. Sackett, B. Barraclough, T. S. Reeve, and L. W. Delbridge, “Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy,” Archives of Surgery, vol. 137, no. 9, pp. 1055–1059, 2002. View at Google Scholar · View at Scopus
  4. R. Udelsman, “Six hundred fifty-six consecutive explorations for primary hyperparathyroidism,” Annals of Surgery, vol. 235, no. 5, pp. 665–672, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Westerdahl, P. Lindblom, and A. Bergenfelz, “Measurement of intraoperative parathyroid hormone predicts long-term operative success,” Archives of Surgery, vol. 137, no. 2, pp. 186–190, 2002. View at Google Scholar · View at Scopus
  6. G. L. Irvin, D. M. Carneiro, and C. C. Solorzano, “Progress in the operative management of sporadic primary hyperparathyroidism over 34 years,” Annals of Surgery, vol. 239, no. 5, pp. 704–708, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. C. S. Grant, G. Thompson, D. Farley et al., “Primary hyperparathyroidism surgical management since the introduction of minimally invasive parathyroidectorny: Mayo Clinic experience,” Archives of Surgery, vol. 140, no. 5, pp. 472–478, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. G. Akerstrom, J. Malmaeus, and R. Bergstrom, “Surgical anatomy of human parathyroid glands,” Surgery, vol. 95, no. 1, pp. 14–21, 1984. View at Google Scholar · View at Scopus
  9. N. W. Thompson, F. E. Eckhauser, and J. K. Harness, “The anatomy of primary hyperparathyroidism,” Surgery, vol. 92, no. 5, pp. 814–821, 1982. View at Google Scholar · View at Scopus
  10. B. Givi and J. P. Shah, “Parathyroid carcinoma,” Clinical Oncology, vol. 22, no. 6, pp. 498–507, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. R. A. Wermers, S. Khosla, E. J. Atkinson et al., “Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993–2001: an update on the changing epidemiology of the disease,” Journal of Bone and Mineral Research, vol. 21, no. 1, pp. 171–177, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. H. Heath III, S. F. Hodgson, and M. A. Kennedy, “Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community,” The New England Journal of Medicine, vol. 302, no. 4, pp. 189–193, 1980. View at Google Scholar · View at Scopus
  13. H. Chen, S. Parkerson, and R. Udelsman, “Parathyroidectomy in the elderly: do the benefits outweigh the risks?” World Journal of Surgery, vol. 22, no. 6, pp. 531–536, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Uden, A. Chan, Q. Y. Duh, A. Siperstein, O. H. Clark, and G. L. Irvin, “Primary hyperparathyroidism in younger and older patients: symptoms and outcome of surgery,” World Journal of Surgery, vol. 16, no. 4, pp. 791–797, 1992. View at Google Scholar · View at Scopus
  15. A. Arnold, H. G. Kim, R. D. Gaz et al., “Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma,” Journal of Clinical Investigation, vol. 83, no. 6, pp. 2034–2037, 1989. View at Google Scholar · View at Scopus
  16. C. Heppner, M. B. Kester, S. K. Agarwal et al., “Somatic mutation of the MEN 1 gene in parathyroid tumours,” Nature Genetics, vol. 16, no. 4, pp. 375–378, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. J. D. Carpten, C. M. Robbins, A. Villablanca et al., “HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome,” Nature Genetics, vol. 32, no. 4, pp. 676–680, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. T. Christensson, “Hyperparathyroidism and radiation therapy,” Annals of Internal Medicine, vol. 89, no. 2, pp. 216–217, 1978. View at Google Scholar · View at Scopus
  19. M. S. Eigelberger, W. K. Cheah, P. H. Ituarte, L. Streja, Q. Y. Duh, and O. H. Clark, “The NIH criteria for parathyroidectomy in asymptomatic primary hyperparathyroidism: are they too limited?” Annals of Surgery, vol. 239, no. 4, pp. 528–535, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. P. Bilezikian and J. P. Potts, “Asymptomatic primary hyperparathyroidism: new issues and new questions,” Journal of Bone and Mineral Research, vol. 17, no. 2, pp. N57–N67, 2002. View at Google Scholar · View at Scopus
  21. A. J. Coakley, A. G. Kettle, C. P. Wells et al., “99Tcm sestamibi: a new agent for parathyroid imaging,” Nuclear Medicine Communications, vol. 10, no. 11, pp. 791–794, 1989. View at Google Scholar · View at Scopus
  22. M. Ishibashi, H. Nishida, Y. Hiromatsu et al., “Comparison of technetium-99m-MIBI, technetium-99 m-tetrofosmin, ultrasound and MRI for localization of abnormal parathyroid glands,” Journal of Nuclear Medicine, vol. 39, no. 2, pp. 320–324, 1998. View at Google Scholar · View at Scopus
  23. O. Geatti, B. Shapiro, P. G. Orsolon et al., “Localization of parathyroid enlargement: experience with technetium-99 m methoxyisobutylisonitrile and thallium-201 scintigraphy, ultrasonography and computed tomography,” European Journal of Nuclear Medicine, vol. 21, no. 1, pp. 17–22, 1994. View at Google Scholar · View at Scopus
  24. B. B. Peeler, W. H. Martin, M. P. Sandler, and R. E. Goldstein, “Sestamibi parathyroid scanning and preoperative localization studies for patients with recurrent/persistent hyperparathyroidism or significant comorbid conditions: development of an optimal localization strategy,” American Surgeon, vol. 63, no. 1, pp. 37–46, 1997. View at Google Scholar · View at Scopus
  25. B. Chiu, C. Sturgeon, and P. Angelos, “What is the link between nonlocalizing sestamibi scans, multigland disease, and persistent hypercalcemia? A study of 401 consecutive patients undergoing parathyroidectomy,” Surgery, vol. 140, no. 3, pp. 418–422, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. D. M. Carniero-Pla, C. C. Solorzano, and G. L. Irvin, “Consequences of targeted parathyroidectomy guide by localizing studies without intraoperative parathyroid hormone monitoring,” Journal of the American College of Surgeons, vol. 202, no. 5, pp. 715–722, 2006. View at Google Scholar
  27. L. Yip, D. A. Pryma, J. H. Yim, M. A. Virji, S. E. Carty, and J. B. Ogilvie, “Can a lightbulb sestamibi SPECT accurately predict single-gland disease in sporadic primary hyperparathyroidism?” World Journal of Surgery, vol. 32, no. 5, pp. 784–792, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. C. J. Palestro, M. B. Tomas, and G. G. Tronco, “Radionuclide imaging of the parathyroid glands,” Seminars in Nuclear Medicine, vol. 35, no. 4, pp. 266–276, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. L. Yip, D. A. Pryma, J. Yim, S. E. Carty, and J. B. Ogilvie, “Sestamibi SPECT intensity scoring system in sporadic primary hyperparathyroidism,” World Journal of Surgery, vol. 33, no. 3, pp. 426–433, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. A. Serra, P. Bolasco, L. Satta, A. Nicolosi, A. Uccheddu, and M. Piga, “Role of SPECT/CT in the preoperative assessment of hyperparathyroid patients,” Radiologia Medica, vol. 111, no. 7, pp. 999–1008, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. W. C. Lavely, S. Goetze, K. P. Friedman et al., “Comparison of SPECT/CT, SPECT, and planar imaging with single- and dual-phase 99mTc-sestamibi parathyroid scintigraphy,” Journal of Nuclear Medicine, vol. 48, no. 7, pp. 1084–1089, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. D. R. Neumann, N. A. Obuchowski, and F. P. Difilippo, “Preoperative 123I/99mTc-sestamibi subtraction SPECT and SPECT/CT in primary hyperparathyroidism,” Journal of Nuclear Medicine, vol. 49, no. 12, pp. 2012–2017, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. R. Prommegger, G. Wimmer, C. Profanter et al., “Virtual neck exploration: a new method for localizing abnormal parathyroid glands,” Annals of Surgery, vol. 250, no. 5, pp. 761–765, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. G. Wimmer, R. Bale, P. Kovacs et al., “Virtual neck exploration in patients with hyperparathyroidism and former cervical operations,” Langenbeck's Archives of Surgery, vol. 393, no. 5, pp. 687–692, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. D. S. Levine, A. S. Belzberg, and S. M. Wiseman, “Hybrid SPECT/CT imaging for primary hyperparathyroidism: case reports and pictorial review,” Clinical Nuclear Medicine, vol. 34, no. 11, pp. 779–784, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. G. Pata, C. Casella, S. Besuzio et al., “Clinical appraisal of 99m technetium-sestamibi SPECT/CT compared to conventional SPECT in patients with primary hyperparathyroidism and concomitant nodular goiter,” Thyroid, vol. 20, no. 10, pp. 1121–1127, 2010. View at Google Scholar
  37. R. Núñez, “Acquisition parameters for oncologic imaging with a new SPECT/multislice CT scanner,” Molecular Imaging and Biology, vol. 12, no. 2, pp. 110–138, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus