Functional Imaging of Pheochromocytoma with ⁶⁸Ga-DOTATOC and ⁶⁸C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia

Figure 1

Histopathological and immunohistopathological comparison of MENX mutant rats ((a), (c), (e)) versus normal control rat ((b), (d), (f)). (a) Histology of the right adrenal gland of the normal rat N2 (H&E). (b) Histology of the left adrenal gland of the mutant rat M2 (H&E). (c) Immunohistochemical staining for p27Kip1 of the same gland as in (a). (d) Immunohistochemical staining for p27Kip1 of the same gland as in (b). (e) Immunohistochemical staining for the proliferation marker Ki67 of the same gland as in a. (f) Immunohistochemical staining for the proliferation marker Ki67 of the same gland as in (b). M, adrenal medulla. Original magnifications: (a), (b) ×20; (c)–(f) ×160.

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