Research Article
Functional Imaging of Pheochromocytoma with 68Ga-DOTATOC and 68C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia
Table 1
Anatomical and functional quantification of the adrenals in MENX mutant rats compared to normal controls.
| | Right adrenal | Left adrenal |
| | | [68Ga]DOTATOC SUV | [11C]HED adrenal/liver | Volume (mm3) | Proliferation index (range) | [68Ga]DOTATOC SUV | [11C]HED adrenal/liver | Volume (mm3) | Proliferation index (range) |
| | Wild-type control rats (wt/wt) |
| | N1 | 23.189 | 0.921 | 120.7 | <2% | 25.331 | 0.780 | 96.3 | <2% | | N2 | 15.177 | 0.725 | 98.35 | <2% | 15.703 | 0.720 | 91.62 | <2% | | N3 | 6.944 | 0.634 | 121.0 | <2% | 6.301 | 0.517 | 116.86 | <2% |
| | Mutant rats (mut/mut) |
| | M1 | 21.479 | 1.370 | 162.24 | 6.6% (4.2–10.2) | 24.077 | 1.326 | 168.94 | 16.7% (4.2–12.5)* | | M2 | 19.088 | 1.270 | 165.51 | 3.7% (1.6–5.7) | 16.857 | 1.368 | 176.99 | 11.6% (4.3–18.9)* | | M3 | 23.797 | 2.193 | 638.93 | 13% (3.4–22.5)* | 26.096 | 2.709 | 317.11 | 52% (50–54) | | M4 | 28.173 | 1.361 | 132.67 | n.d. | 26.598 | 1.375 | 135.71 | 5.1% (2.8–8.3) |
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*Ki67 staining pattern is very heterogeneous: some areas have low, others have high Ki67 immunoreactivity.
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