Table of Contents
International Journal of Molecular Imaging
Volume 2011 (2011), Article ID 189830, 8 pages
http://dx.doi.org/10.1155/2011/189830
Research Article

Parametric Images in Assessing Bone Grafts Using Dynamic 18F-Fluoride PET

1Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
2School of Information Technologies, University of Sydney, Sydney, NSW 2006, Australia
3Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong
4Med-X Research Institute, Shanghai JiaoTong University, Shanghai 200030, China
5Department of Orthopedic Surgery, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
6Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia

Received 30 December 2010; Accepted 15 March 2011

Academic Editor: Hongming Zhuang

Copyright © 2011 Lingfeng Wen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The early identification of graft failure would improve patient management. 18F-fluoride is a suitable tracer for quantifying bone metabolism. Performance of parametric images constructed by Patlak graphical analysis (PGA) with various time periods was evaluated in the analysis of dynamic 18F-fluoride PET studies of eight patients with fibula bone grafts after limb salvage surgery. The PGA parametric image approach tended to underestimate influx rate. The linear portion of PGA analysis was found to be from 10 to 50 min. It shows promise in providing a quantitative assessment of the viability of bone grafts.