FDG-PET or PET/CT in Fever of Unknown Origin: The Diagnostic Role of Underlying Primary Disease

Table 1

Review of literature on FDG PET or PET/CT in patients with fever of unknown origin.

Author; (Year)	Study design	Patients number	FDG-PET technique	PET helpful (%)	PPV (%)	NPV (%)
Meller et al.; (2000)	Prospective	18	Coincidence camera	55	92	75
Blockmans et al.; (2001)	Prospective	58	Full-ring PET	41	—	—
Lorenzen et al.; (2001)	Retrospective	16	Full-ring PET	69	92	100
Bleeker-Rovers et al.; (2004)	Retrospective	35	Full-ring PET	37	87	95
Kjaer et al.; (2004)	Prospective	19	Full-ring PET	16	30	67
Buysschaert et al.; (2004)	Prospective	74	Full-ring PET	26	—	—
Bleeker-Rowers et al.; (2007)	Prospective	70	Full-ring PET	33	70	92
Keidar et al.; (2008)	Prospective	48	PET/CT scan	46	81	100
Balink et al.; (2009)	Retrospective	68	PET/CT scan	55	93	78
Federici et al.; (2010)	Retrospective	10	PET/CT scan	50	—	—
Jasper et al.; (2010)	Retrospective	44	Full-ring PET or PET/CT scan	43	—	—
Ferda et al.; (2010)	Retrospective	48	PET/CT scan (contrast-enhanced CT)	89	97	75
Keia et al.; (2010)	Retrospective	12	PET/CT scan	42	71	100
Ergul et al.*	Retrospective	28	PET/CT scan	50	63	100
	Total:	548	Mean values:	47	78	88

*Unpublished data, PPV: positive predictive value, NPV: negative predictive value.