Table of Contents
International Journal of Molecular Imaging
Volume 2011 (2011), Article ID 398051, 8 pages
http://dx.doi.org/10.1155/2011/398051
Research Article

Utility of Quantitative 99mTc-MAA SPECT/CT for 90yttrium-Labelled Microsphere Treatment Planning: Calculating Vascularized Hepatic Volume and Dosimetric Approach

1Department of Nuclear Medicine, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France
2Faculty of Medicine, European University of Brittany, 35043 Rennes, France
3INSERM U991 Liver Metabolisms and Cancer, 35033 Rennes, France
4Department of Medical Imaging, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France
5Department of Medical Oncology, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France
6Department of Medical Informatics, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France

Received 15 March 2011; Accepted 25 May 2011

Academic Editor: Ronald L. Van Heertum

Copyright © 2011 Etienne Garin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The aim of this study was to assess the effectiveness of SPECT/CT for volume measurements and to report a case illustrating the major impact of SPECT/CT in calculating the vascularized liver volume and dosimetry prior to injecting radiolabelled yttrium-90 microspheres (Therasphere). Materials and Methods. This was a phantom study, involving volume measurements carried out by two operators using SPECT and SPECT/CT images. The percentage of error for each method was calculated, and interobserver reproducibility was evaluated. A treatment using Therasphere was planned in a patient with three hepatic arteries, and the quantitative analysis of SPECT/CT for this patient is provided. Results. SPECT/CT volume measurements proved to be accurate (mean error <6% for volumes ≥16 cm3) and reproductive (interobserver agreement = 0.9). In the case report, 99mTc-MAA SPECT/CT identified a large liver volume, not previously identified with angiography, which was shown to be vascularized after selective MAA injection into an arterial branch, resulting in a large modification in the activity of Therasphere used. Conclusions. MAA SPECT/CT is accurate for vascularized liver volume measurements, providing a valuable contribution to the therapeutic planning of patients with complex hepatic vascularization.