Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470
Figure 1
Typical in vivo PET/CT scan images of an adolescent (PND 35–37) and an adult (PND 70–72) Wistar rat in transversal (left) and sagittal (right) planes. For illustration purpose, the absolute binding intensity of [18F]MK-9470 to CB1R (%ID40–60) was increased (Anatomist/BrainVisa, V3.1.4, http://brainvisa.info/) in order to reflect the results expressed in estimated marginal means of %ID40–60, that is, a higher CB1R absolute binding in adults compared to adolescents.
