Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470
Table 1
CB1 receptor in vivo binding levels ([18F]MK-9470) in adolescents and adults rats.
Adolescents
Adults
% change (adjusted)
Unadjusted
Adjusted
Unadjusted
Adjusted
Striatum
0.86 ± 0.07
0.49 ± 0.07
0.38 ± 0.03
0.74 ± 0.07
50.3
Frontal cortex
0.83 ± 0.06
0.47 ± 0.07
0.38 ± 0.03
0.75 ± 0.07
59.8
Cortex
0.83 ± 0.07
0.47 ± 0.07
0.38 ± 0.03
0.74 ± 0.07
58.5
Hippocampus
0.83 ± 0.06
0.47 ± 0.07
0.38 ± 0.03
0.75 ± 0.07
59.9
Thalamus
0.86 ± 0.06
0.49 ± 0.07
0.37 ± 0.03
0.74 ± 0.07
49.1
Hypothalamus
0.86 ± 0.06
0.50 ± 0.07
0.40 ± 0.03
0.76 ± 0.07
52.0
Amygdala
0.81 ± 0.06
0.45 ± 0.07
0.36 ± 0.03
0.73 ± 0.07
63.1
Superior colliculus
0.97 ± 0.07
0.61 ± 0.07
0.42 ± 0.03
0.79 ± 0.07
29.2
Cerebellum
1.04 ± 0.09
0.68 ± 0.07
0.44 ± 0.03
0.80 ± 0.07
18.2
Midbrain
0.90 ± 0.06
0.54 ± 0.07
0.38 ± 0.02
0.75 ± 0.07
38.6
pons
0.95 ± 0.07
0.58 ± 0.07
0.39 ± 0.03
0.75 ± 0.07
29.0
Unadjusted values are mean %ID40–60 ± SEM; adjusted values are estimated marginal means %ID40–60 ± SEM. Two-way ANCOVA controlling for weight was performed ( per group). Covariates appearing in the ANCOVA model are evaluated at the following values: weight = 264.9142.
