Table of Contents
International Journal of Molecular Imaging
Volume 2011 (2011), Article ID 679473, 8 pages
http://dx.doi.org/10.1155/2011/679473
Clinical Study

Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET

1Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9RH, UK
2Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 2PB, UK
3Queensland PET Service, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, Australia

Received 20 January 2011; Accepted 24 February 2011

Academic Editor: Franklin C. L. Wong

Copyright © 2011 K. A. Miles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To assess whether the differences in vascular-metabolic relationships between lymphoma masses and colorectal liver metastases predicted from previous histopathological studies can be demonstrated by dynamic contrast-enhanced CT (DCE-CT) combined with fluorodeoxyglucose positron emission tomography (FDG-PET). Methods. DCE-CT and FDG-PET studies were drawn from an imaging archive for patients with either lymphoma masses () or hepatic metastases from colorectal cancer (CRM: ). Tumour vascularity was assessed using DCE-CT measurements of perfusion. Tumour glucose metabolism was expressed as the mean FDG Standardised Uptake Value (). The relationship between metabolism and vascularity in each group was assessed from /perfusion ratios and Pearson correlation coefficients. Results. An threshold of 3.0 was used to designate lymphoma masses as active (AL, ) or inactive lymphoma (IL, ). Tumour perfusion was significantly higher in AL (0.65 mL/min/mL) than CRM (0.37 mL/min/mL: ) despite similar (5.05 and 5.33, resp.). AL demonstrated higher perfusion values than IL (0.24 mL/min/mL: ). /perfusion was significantly higher in CRM (15.3 min) than IL (4.2 min, ). There was no correlation between and perfusion for any patient group.