Table of Contents
International Journal of Molecular Imaging
Volume 2011, Article ID 682949, 7 pages
Review Article

Ventilation/Perfusion SPECT for Diagnosis of Pulmonary Embolism and Other Diseases

Department of Clinical Physiology, Lund University, 22185 Lund, Sweden

Received 5 October 2010; Accepted 10 November 2010

Academic Editor: Leonard M. Freeman

Copyright © 2011 Marika Bajc and Björn Jonson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


V / P S P E C T has the potential to become a first hand tool for diagnosis of pulmonary embolism based on standardized technology and new holistic interpretation criteria. Pretest probability helps clinicians choose the most appropriate objective test for diagnosis or exclusion of PE. Interpretation should also take into account all ventilation and perfusion patterns allowing diagnosis of other cardiopulmonary diseases than PE. In such contexts, V / P S P E C T has excellent sensitivity and specificity. Nondiagnostic reports are ≤3%. V / P S P E C T has no contraindication; it is noninvasive and has very low radiation exposure. Moreover, acquisition time for V / P S P E C T is only 20 minutes. It allows quantification of PE extension which has an impact on individual treatment. It is uniquely useful for followup and research.