Quantitative Longitudinal Imaging of Vascular Inflammation and Treatment by Ezetimibe in apoE Mice by FMT Using New Optical Imaging Biomarkers of Cathepsin Activity and Integrin
Figure 1
Basic characteristics of cathepsin and integrin agents. (a), (b) Cartoon and spectra of ProSense ~400 kDa polylysine-based [27]; (c), (d) Cartoon and spectra of FAST peptide-based agents ~23 kDa, PKM: pharmacokinetic modifier, absorption spectra (before activation—dash red and after activation: solid red), emission spectra: solid blue; (e), selectivity in cathepsin probe activation at 24 hours incubation; (f), Chemical structure of parent integrin ligand (top) and IntegriSense (bottom, ~1278 Da) NIRF: VivoTag fluorophore.
