Quantitative Longitudinal Imaging of Vascular Inflammation and Treatment by Ezetimibe in apoE Mice by FMT Using New Optical Imaging Biomarkers of Cathepsin Activity and 𝜶_𝑣𝜷_𝟑 Integrin

Table 1

Measurement of IntegriSense selectivity in binding to different integrin receptors IC₅₀ values (mean ± SEM) of IntegriSense 750 and Parent Compound in cell adhesion assays.

	IC50 (nM)
	IntegriSense 750	Parent compound
α vβ 3	3.5 ± 0.2	0.82 ± 0.2
α vβ 5	41 ± 12	1.3 ± 0.2
α IIbβ 3	48 ± 15	>10,000
𝛼5𝛽1^∗	>5,000	>10,000

^*Binding assays to vitronectin were performed for all integrin receptors except 𝛼₅𝛽₁ which was performed on fibronectin.