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Authors | Study design | Device | Injected activity | Time between tracer injection and image acquisition (min) | PET acquisition protocol | Image analysis | Reference standard | Sensitivity of FDOPA-PET or PET/CT* | Specificity of FDOPA-PET or PET/CT* |
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Treglia et al. [5] | Retrospective multicenter | PET/CT | 4 MBq/kg | 60 | Static acquisition (3 min per bed position)no carbidopa premedication | Qualitative | Histology and/or clinical/imaging followup | 72% | NC |
Kauhanen et al. [6] | Prospective multicenter | PET/CT | 243 MBq | 60 | Static acquisition (3 min per bed position)carbidopa premedication | Qualitative and semiquantitative | Histology and/or clinical/imaging followup | 58% | NC |
Luster et al. [11] | Retrospective single center | PET/CT | 298 MBq | 60 | Static acquisition (4 min per bed position)carbidopa premedication | Qualitative and semiquantitative | Histology and/or clinical/imaging followup | 74% | 100% |
Marzola et al. [13] | Multicenter | PET/CT | 2.2 MBq/kg | 60 | Static acquisition (3 min per bed position)no carbidopa premedication | Qualitative and semiquantitative | Histology | 83% | NC |
Beheshti et al. [16] | Prospective single center | PET/CT | 4 MBq/Kg | 30 | Static acquisition (4 min per bed position)no carbidopa premedication | Qualitative and semiquantitative | Histology and/or clinical/imaging followup | 81% | NC |
Koopmans et al. [18] | Prospective single center | PET | 180 MBq | 60 | Static acquisition; (5 min per bed position)carbidopa premedication | Qualitative | Histology and/or clinical/imaging followup | 62% | NC |
Beuthien-Baumann et al. [23] | Retrospective single center | PET | 4.8 MBq/Kg | 45 | Static acquisition carbidopa premedication | Qualitative | Histology and/or clinical/imaging followup | 47% | NC |
Hoegerle et al. [30] | Prospective single center | PET | 220 MBq | 90 | Static acquisition no carbidopa premedication | Qualitative | Histology and/or clinical/imaging followup | 60% | NC |
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