⁶⁴Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin 𝜶_𝑉𝜷_𝟑 Expression in Human Neuroendocrine Tumor Xenografts

Table 4

OLINDA estimated radiation-absorbed doses for human adults after injection of  ⁶⁴Cu-NODAGA-c(RGDyK).

Target organ	Organ doses (mGy/MBq)
	Adult female	Adult male
Adrenals	1.45𝐸−04	1.14𝐸−04
Brain	1.25𝐸−04	9.76𝐸−05
Breasts	1.18𝐸−03	9.23𝐸−04
Gallbladder wall	0.00𝐸000	0.00𝐸000
Lower large intestine wall	3.93𝐸−03	3.10𝐸−03
Small intestine	2.88𝐸−04	2.46𝐸−04
Stomach wall	3.43𝐸−03	2.71𝐸−03
Upper large intestine wall	1.58𝐸−04	1.25𝐸−04
Heart wall	0.00𝐸000	0.00𝐸000
Kidneys	3.48𝐸−04	3.16𝐸−04
Liver	1.28𝐸−03	9.73𝐸−04
Lungs	1.10𝐸−03	8.68𝐸−04
Muscle	1.34𝐸−04	1.06𝐸−04
Ovaries/testicles	6.62𝐸−03	5.28𝐸−03
Pancreas	1.48𝐸−04	1.17𝐸−04
Red marrow	2.72𝐸−03	2.19𝐸−03
Osteogenic cells	5.74𝐸−04	4.28𝐸−04
Skin	2.32𝐸−04	1.83𝐸−04
Spleen	7.83𝐸−05	6.37𝐸−05
Thymus	1.33𝐸−04	1.03𝐸−04
Thyroid	1.28𝐸−03	1.06𝐸−03
Urinary bladder wall	1.37𝐸−02	1.03𝐸−02
Uterus	1.79𝐸−04	1.46𝐸−04
Total body	0.00𝐸000	0.00𝐸000
Effective dose (mSv/MBq)	3.78𝐸−02	2.94𝐸−02

Estimated doses based on average biodistribution in organs at 1, 2, and 18 hours post injection obtained in human neuroendocrine xenograft tumor mice.