Contribution of 18F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours: First Clinical Experience
Table 1
Patient and tumour characteristics and volumetric results of MRI/CT and FET-PET in 14 patients with skull base tumours.
Patient
Sex
Age
Histology
Diagnostic modalities
Location
Infiltration of bone
Infiltration of brain
Previous therapy
(cm3)
(cm3)
(cm3)
(cm3)
(cm3/%)1
(cm3/%)1
(cm3)
(%)2
Bidirectional change of
(cm3/%)3
1
F
57
Adenoid cystic
CT MRI PET
Skull base
Petrous bone
None
Surg Rad Chemo
100
81
106
77
6/6
6
17/17*
89
84*
23/26*
2
M
47
SCC
CT MRI PET
Auditory canal
Posterior scull base
None
Surg Rad Chemo
104
62
105
50
0.5/0.5
17
37/36*
68
65*
38/56*
3
F
58
Esthesio-neuroblastoma
CT MRI PET
Anterior skull base
Anterior skull base
Frontal lobe
Surg Rad Chemo
84
80
84
64
0/0
1.5
19/23*
66
78*
19/29*
4
M
75
SCC
CT PET
Maxillary sinus
Maxillary sinus
None
None
127
130
127
99
0/0
11
18/14*
110
87*
18/16*
5
M
61
Chordoma
CT PET
Sella
Sphenoid bone
None
Surg
0.5
1.6
0.5
0.5
0/0
0
0/0
0.5
100
0/0
6
F
48
SCC
CT MRI PET
Naso-pharynx
Anterior skull base
None
Surg Rad
27
21
27
17
0/0
2
8/30*
19
70*
8/42*
7
F
79
SCC
CT PET
Sphenoid sinus
Sphenoid bone
None
Rad
11
13
11
4
0/0
1
6/55*
5
45*
6/120*
8
F
24
Sarcoma
CT MRI PET
Cranio-facial
Cranio-facial
None
Surg Rad
6
8
7
5
1/17*
0.5
0.5/8
7
93
1.5/23*
9
F
55
SCC
CT MRI PET
Naso-pharynx
Anterior skull base
None
Surg Rad Chemo
34
22
34
13
0.4/1
6
15/44*
19
56*
15/79*
10
M
47
SCC
CT MRI PET
Cavum nasi
Anterior skull base
Frontal lobe
Surg Rad Chemo
4
5
5
2
1/25*
1
0.4/10
4
80*
1.4/35*
11
F
53
SCC
CT MRI PET
Naso-pharynx
Anterior skull base
Frontal lobe
None
57
48
57
39
0/0
9
10/18*
48
84*
10/21
12
M
73
SCC
CT MRI PET
Naso-pharynx
Anterior skull base
Frontal lobe
None
26
21
27
16
1/4
1.5
8/31*
19
69*
9/49*
13
M
50
SCC
CT MRI PET
Petrous bone
Petrous bone
Cere-bellum
Rad
33
8
38
23
5/15*
3
7/21*
31
82*
12/39*
14
M
72
SCC
CT MRI PET
Skull base
Sphenoid bone
Temporal lobe
Rad
28
21
30
15
2/7
5
8/29*
22
73*
10/46*
Mean ±SD
58 ±15
45 ±42
37 ±38
47 ±42
30 ±31
1/5 ±2/±8
5 ±5
11/24* ±10/±15
36 ±35
77* ±14
12/41* ±10/±30
1% of ; 2% of ; 3% of ; 4Radiation field; *more than 10%. change from . F: female, M: male, SCC: squamous cell cancer; CT: computed tomography, MRI: magnetic resonance imaging, PET: positron emission tomography, Surg: surgery, Rad: radiation therapy, Chemo: chemotherapy, GTV: gross tumour volume, : GTV by MRI or CT, : GTV by PET, : GTV by MRI/CT or PET, : GTV by MRI/CT and PET, : GTV by PET not shown in GTV MRI/CT, : GTV by MRI/CT not shown in GTV PET, : GTV by and , : GTV only by MRI/CT excluded from final GTV, SD: standard deviation.
