Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D2/3 Receptors

<div>Compilation of the applied chemical conversions. Preparative synthesis includes the following: (i) hexa-n-butylditin, Pd(PPh3)4, and dioxane, 100°C. “Cold” labelling tests include the following: (ii) NaI, H2O2, and acetic acid/acetate buffer, rt. Radiolabelling includes the following: (iii) [123I]-NaI, H2O2, and HOAc/NH4OAc buffer and (iv) H2SO4, ethanol, and heat.</div>

International Journal of Molecular Imaging

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Scheme 1: Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D2/3 Receptors

Scheme 1 | Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D2/3 Receptors 