Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D_2/3 Receptors

Table 2

Brain areas to cerebellum uptake ratios at different times after intravenous injection of [¹²³I]-1.

	15 min	30 min	1 h	2 h	3 h	4 h	24 h
Pituitary/cereb.	1.157^*	2.262 ± 0.233	2.502 ± 0.883	4.399 ± 2.113	3.352 ± 1.490	3.570 ± 2.544	6.021 ± 0.577
Olfactory b./cereb.	0.431 ± 0.330	0.893 ± 0.067	1.007 ± 0.050	1.125 ± 0.089	1.314 ± 0.150	1.333 ± 0.124	1.444 ± 0.163
Frontal cortex/cereb.	2.962 ± 1.817	1.543 ± 0.142	1.154 ± 0.095	1.145 ± 0.079	1.315 ± 0.360	0.865 ± 0.580	1.818 ± 0.372
Striatum/cereb.	1.455 ± 1.265	1.294 ± 0.061	1.246 ± 0.103	1.155 ± 0.069	1.331 ± 0.126	1.156 ± 0.080	2.023 ± 0.872
Hypothalamus/cereb.	1.512 ± 0.546	1.139 ± 0.014	1.189 ± 0.132	1.116 ± 0.085	1.326 ± 0.053	1.332 ± 0.103	1.989 ± 0.574
Thalamus/cereb.	1.670 ± 0.908	1.325 ± 0.074	1.243 ± 0.042	1.200 ± 0.067	1.582 ± 0.101	1.351 ± 0.175	2.473 ± 0.599
Hippocampus/cereb.	0.870 ± 0.303	1.479 ± 0.466	1.390 ± 0.210	1.301 ± 0.047	1.294 ± 0.112	1.035 ± 0.114	1.031 ± 0.090
Midbrain/cereb.	3.712 ± 4.715	1.144 ± 0.051	1.207 ± 0.109	1.168 ± 0.080	1.224 ± 0.090	1.097 ± 0.086	1.426 ± 0.204
Pons/medulla/cereb.	1.470 ± 0.520	1.036 ± 0.212	1.218 ± 0.109	1.205 ± 0.016	1.310 ± 0.114	1.214 ± 0.133	1.278 ± 0.211

At this time point and in this brain area, only 1 sample was available.