Beneficial Effect of Glucose Control on Atherosclerosis Progression in Diabetic ApoE−/− Mice: Shown by Rage Directed Imaging
Atherosclerotic lesions and SPECT/CT scans. Each panel shows in situ dissection on top and in middle and lower panels coronal and transverse slices from SPECT/CT scans with IV contrast. Panel (a) is an example of a treated mouse and panel (b) is an example of an untreated mouse injected with -anti-RAGE and panel (c) is an example of an untreated mouse injected with control antibody. There is less extensive atheroma in the treated mouse compared to the two untreated mice. The CT contrast delineates the ventricular cavities and arterial vessels. Regions of uptake of the -anti-RAGE (blue arrows) are seen localized to the proximal aorta in the treated mouse and are more extensive in the ascending aorta and arch in the untreated mouse. No uptake is seen in the mouse injected with control antibody despite extensive atherosclerotic disease.