Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy

Figure 2

Pharmacokinetics of rAAT. The concentration time profiles of rAAT in serum (a) and tissues (b, c) in male Balb/c mice following a single dose of 2 mg/kg [¹²⁵I]rAAT via IV route (b) or 5 mg/kg via IT route (c). The PK parameters following 2 mg/kg IV administration of [¹²⁵I]rAAT are listed in (d).

(a)

(b)

(c)

(d)