Table of Contents
International Journal of Molecular Imaging
Volume 2016 (2016), Article ID 6045894, 5 pages
http://dx.doi.org/10.1155/2016/6045894
Research Article

A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma

1Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7
2Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
3Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8

Received 15 December 2015; Accepted 5 May 2016

Academic Editor: J. M. Mountz

Copyright © 2016 Danny L. Costantini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV and , versus 18F-FDG SUV and , resp., ). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of and , respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.