Table of Contents
Indian Journal of Materials Science
Volume 2015, Article ID 312934, 9 pages
http://dx.doi.org/10.1155/2015/312934
Research Article

Evaluation of Chitosan Based Polymeric Matrices for Sustained Stomach Specific Delivery of Propranolol Hydrochloride

Department of Pharmaceutics, IFTM University, Moradabad 244001, India

Received 29 May 2015; Revised 9 July 2015; Accepted 14 July 2015

Academic Editor: Marino Lavorgna

Copyright © 2015 Juhi Dubey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of the present investigation was to explore the potential of Chitosan based polymeric matrices as carrier for sustained stomach specific delivery of model drug Propranolol Hydrochloride. Briefly, single unit hydrodynamically balanced (HBS) capsule formulations were prepared by encapsulating in hard gelatin capsules, intimately mixed physical mixtures of drug, and cationic low molecular weight Chitosan (LMCH) in combination with either anionic medium viscosity sodium alginate (MSA) or sodium carboxymethylcellulose (CMCNa). The effect of incorporation of nonionic polymers, namely, tamarind seed gum (TSG) and microcrystalline cellulose (MCCP), was also investigated. It was observed that HBS formulations remained buoyant for up to 6 h in 0.1 M HCl, when LMCH : anionic/nonionic polymer ratio was at least 4 : 1. It was also observed that LMCH has formed polyelectrolyte complex (PEC) with MSA (4 : 1.5 ratio) and CMCNa (4 : 1 ratio) in situ during the gelation of HBS formulations in 0.1 M HCl. The retardation in drug release was attributed to the PEC formation between LMCH and MSA/CMCNa. Incorporation of MCCP (rapid gel formation) and TSG (Plug formation) was found to be innovative. From the data, it is suggested that Chitosan based polymeric matrices may constitute an excellent carrier for stomach specific drug delivery.