Effect of Microwave Radiation on Enzymatic and Chemical Peptide Bond Synthesis on Solid Phase
Scheme 1
Synthesis of Fmoc-Phe-Phe-PEG under
microwave radiation via
enzymatic and chemical coupling. (a) (i) DIC/DMAP in DMF; (ii) Pyp 20%. (b)
Chemical coupling (DIC/HOBt in DMF) or enzymatic coupling (Thermolysin in
aqueous buffer) (see Supplementary Material available online at doi:10.1155/2009/362482).
