Synthesis of Peptides from α- and β-Tubulin Containing Glutamic Acid Side-Chain Linked Oligo-Glu with Defined Length
Figure 2
Scheme for the assembly of the carboxy-terminal sequence of α1-tubulin containing a side-chain oligo-glutamic acid branched glutamic acid at position 15 of the sequence. The corresponding β1-tubulin peptides (CQDATADEQG-E(Ex)-FEEEEGEDEA) were assembled accordingly ( to 5, corresponding to the incrementations a to e of the numbering of the compounds).