Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Table 4

Effects of GHSR antagonists on glucose and insulin levels.


Species	Treatment Administration	Dose	Feeding	Measurement blood samples	Plasma glucose levels	Plasma insulin levels	Reference

Mice ob/ob	1 IP GHSR antagonist injection/12 hours versus 1 IP placebo injection	200 nmol GHRP-6/mouse	Ad libitum SCD	Endpoint 6-day	Diminished	Diminished	[75]

Mice ddY	1 IP GHSR antagonist injection versus 1 IP placebo injection	10 mol GHRP-6/kg	Fasting overnight	Time course 2 hours	Diminished	Enhanced
	1 IP GHSR antagonist injection versus 1 IP placebo injection	1 mol SPA/kg	Fasting overnight	Time course 2 hours	Diminished	Enhanced	[58]
	1 IP GHSR antagonist + ghrelin injection versus 1 IP ghrelin injection	1 mol GHRP-6/kg +10 nmol ghrelin/kg	Fasting overnight	End point 0.5 hours	Diminished

Normal rats	1 IP GHSR antagonist injection versus 1 IP placebo injection	10 mol GHRP-6/kg	Fasting overnight	End point 0.5 hours		Enhanced	[91]
Gastrectomized rats	1 IP GHSR antagonist injection versus 1 IP placebo injection	10 mol GHRP-6/kg	Fasting overnight	End point 0.5 hours		Enhanced	[91]

Normal rats	Oral GHSR antagonist + IP-GTT versus IP-GTT	10 mg YIL-781/kg +2 g glucose/kg	Fasting overnight	Time course 6 hours	Diminished	Enhanced	[92]
Normal rats	Oral GHSR antagonist versus placebo	30 mg YIL-781/kg	Fasting overnight	Time course 6 hours	Diminished
DIO rats	Oral GHSR antagonist +IP-GTT versus placebo + IP-GTT	3 mg YIL-781/kg +2 g glucose/kg	Fasting overnight	Time course 6.5 hours	Diminished