International Journal of Peptides / 2010 / Article / Tab 4

Review Article

Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Table 4

Effects of GHSR antagonists on glucose and insulin levels.

SpeciesTreatment AdministrationDoseFeedingMeasurement blood samplesPlasma glucose levelsPlasma insulin levelsReference

Mice ob/ob1 IP GHSR antagonist injection/12 hours versus 1 IP placebo injection200โ€‰nmol GHRP-6/mouseAd libitum SCDEndpoint 6-dayDiminishedDiminished [75]

Mice ddY1 IP GHSR antagonist injection versus 1 IP placebo injection10โ€‰ ๐œ‡ mol GHRP-6/kgFasting overnightTime course 2 hoursDiminishedEnhanced
1 IP GHSR antagonist injection versus 1 IP placebo injection1โ€‰ ๐œ‡ mol SPA/kgFasting overnightTime course 2 hoursDiminishedEnhanced [58]
1 IP GHSR antagonist + ghrelin injection versus 1 IP ghrelin injection1โ€‰ ๐œ‡ mol GHRP-6/kg +10โ€‰nmol ghrelin/kgFasting overnightEnd point 0.5 hoursDiminished

Normal rats1 IP GHSR antagonist injection versus 1 IP placebo injection10โ€‰ ๐œ‡ mol GHRP-6/kgFasting overnightEnd point 0.5 hoursEnhanced [91]
Gastrectomized rats1 IP GHSR antagonist injection versus 1 IP placebo injection10โ€‰ ๐œ‡ mol GHRP-6/kgFasting overnightEnd point 0.5 hoursEnhanced

Normal ratsOral GHSR antagonist + IP-GTT versus IP-GTT10โ€‰mg YIL-781/kg +2โ€‰g glucose/kgFasting overnightTime course 6 hoursDiminishedEnhanced [92]
Oral GHSR antagonist versus placebo30โ€‰mg YIL-781/kgFasting overnightTime course 6 hoursDiminished
DIO ratsOral GHSR antagonist +IP-GTT versus placebo + IP-GTT3โ€‰mg YIL-781/kg +2โ€‰g glucose/kgFasting overnightTime course 6.5 hoursDiminished