International Journal of Peptides / 2010 / Article / Tab 6

Review Article

Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Table 6

Relation between overexpression of ghrelin in different tissues or cellular types and glucose-insulin levels.

Transgenic animalsGhrelin levelstransgenic versus wildtypeTreatmentFood before/during experimentTreatment durationPlasma glucose levels transgenic versus wildtypePlasma insulin levels transgenic versus wildtypeReference

Ghrelin is overexpressed inadipose tissueAG: not change UAG: enhancedNothingAd libitumEndpointEnhanced [26]
IP-GTT16-h fast2.5 hoursDiminished
IP-ITT16-h fast2.5 hoursDiminished

Ghrelin is overexpressed in stomach and hypothalamusAG: enhanced UAG: enhancedIP-GTT18-h fast2.5 hoursEnhancedDiminished [113]
IP-ITT4-h fast2.5 hoursNot changeNot change

Ghrelin is overexpressed in pancreasAG: not change UAG: enhancedNothingOvernight fastEndpointNot changeNot change [39]
IP-GTTOvernight fast2 hoursNot changeDiminished
IP-GTTOvernight fast2 hoursNot changeDiminished
ITT4-h fast3 hoursNot changeNot change

Ghrelin is overexpressed in hypothalamus, cortex and liverAG: enhanced UAG: enhancedIP-GTT20-h fast2 hoursEnhancedNot change [114]
Ghrelin is overexpressed in hypothalamus, cortex and liverAG: not change UAG: enhancedIP-GTT20-h fast2 hoursNot changeNot change

Ghrelin is overexpressed in wide variety of tissuesAG: not change UAG: enhancedNothingAd libitumEndpointNot changeNot change [27]