Ghrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility
Figure 3
Effects of des-acyl ghrelin on the gastroduodenal motility. (a) Effects of i.v. injection of des-acyl ghrelin on the fasted motor activities of the antrum and duodenum. I.v. injection of des-acyl ghrelin decreases the frequency of phase III-like contractions in the antrum but not in the duodenum. (b) The decreased frequency of phase III-like contractions induced by i.v. injection of des-acyl ghrelin is restored to normal in pretreatment of i.c.v. injection of the selective CRF type 2 receptor antagonist antisauvagine-30. (c) The density of c-Fos-positive cells in the PVN is increased by i.p. injection of des-acyl ghrelin compared to saline-injected control, whereas that in the NTS is not altered. (d) Summary diagram of the effects of des-acyl ghrelin on the gastroduodenal motility and brain mechanism mediating its action.
