Ghrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility

Table 1

Summary of the regulatory roles of ghrelin, des-acyl ghrelin and obestatin on the gastroduodenal motility.

	ghrelin		des-acyl ghrelin		obestatin
	Fasted state	Fed state	Fasted state	Fed state	Fasted state	Fed state
Stomach	↑	↑	↓	—	—	↓
Duodenum	↑	↑	—	—	—	↓
Hypothalamic neuron	NPY		urocortin 2		CRF, urocortin 2
Brain receptor	Y2, Y4		CRF type 2		CRF type 1, type 2
Vagal afferent pathway	+		—		+