Use of Ghrelin as a Treatment for Inflammatory Bowel Disease: Mechanistic Considerations
Efficacy of ghrelin as a treatment for TNBS colitis. For each set of experiments shown, TNBS colitis was induced via intrarectal injection on day 0 while control mice received 50% ethanol. Mice in (a) were given ghrelin as a rescue medication on days 6–9 of colitis and exhibited a rapid improvement in weight and in macroscopic score. Mice in (b) and (c) were given a single ghrelin injection 12 hours after TNBS treatment and had histology (b) and serum cytokines (c) examined on day 3 after treatment. * versus TNBS (adapted from Gastroenterology 130: 1707–1720, used by permission).