Table of Contents
International Journal of Peptides
Volume 2011, Article ID 217957, 5 pages
http://dx.doi.org/10.1155/2011/217957
Review Article

Ghrelin O-Acyl Transferase: Bridging Ghrelin and Energy Homeostasis

Laboratory of Integrative Neuroendocrinology, Department of Biology, York University, Toronto, ON, M3J 1P3, Canada

Received 3 May 2011; Accepted 20 July 2011

Academic Editor: Lloyd D. Fricker

Copyright © 2011 Andrew Shlimun and Suraj Unniappan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ghrelin O-acyl transferase (GOAT) is a recently identified enzyme responsible for the unique n-acyl modification of ghrelin, a multifunctional metabolic hormone. GOAT structure and activity appears to be conserved from fish to man. Since the acyl modification is critical for most of the biological actions of ghrelin, especially metabolic functions, GOAT emerged as a very important molecule of interest. The research on GOAT is on the rise, and several important results reiterating its significance have been reported. Notable among these discoveries are the identification of GOAT tissue expression patterns, effects on insulin secretion, blood glucose levels, feeding, body weight, and metabolism. Several attempts have been made to design and test synthetic compounds that can modulate endogenous GOAT, which could turn beneficial in favorably regulating whole body energy homeostasis. This paper will focus to provide an update on recent advances in GOAT research and its broader implications in the regulation of energy balance.