Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro
Osteoclast activity in mouse calvarial culture is not affected by ghrelin. Calvariae labeled in vivo with 45Ca were collected and incubated ex vivo with experimental substances or vehicle for 48 hours. Values are expressed as percent released 45Ca detected over total 45Ca injected (3 μCi). PTH: parathyroid hormone (positive control). Data are mean ± SEM; *indicates compared to untreated control.