Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro

<table>Osteoclast activity in mouse calvarial culture is not affected by ghrelin. Calvariae labeled in vivo with <sup>45</sup>Ca were collected and incubated ex vivo with experimental substances or vehicle for 48 hours. Values are expressed as percent released <sup>45</sup>Ca detected over total <sup>45</sup>Ca injected (3 <i>μ</i>Ci). PTH: parathyroid hormone (positive control). Data are mean ± SEM; *indicates <svg height="11.25" id="M4" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 61.362499 11.25" width="61.362499" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</g>
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</svg>compared to untreated control.</table>

International Journal of Peptides

fig3

Figure 3

Figure 3: Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro 